Kv7.2/Kv7.3 activator-3, CAS [[1361107-81-4]] Preis auf Anfrage

Product Overview

• Article Name: Kv7.2/Kv7.3 activator-3, CAS [[1361107-81-4]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-175340
• Supplier Catalog Number: HY-175340
• Alternative Catalog Number: MCE-HY-175340-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active Kv7.2/Kv7.3 and TSPO activator. Kv7.2/Kv7.3 activator-3 activates Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 µM, respectively, and binds to TSPO with Ki values of 0.07 µM (rat membrane) and 4.60 µM (human U-118 MG cells). Kv7.2/Kv7.3 activator-3 prevents motor neuron degeneration in mice and humans conditioned by ALS/FTD astrocytes. Kv7.2/Kv7.3 activator-3 stimulates dorsal root ganglion axonal growth through TSPO and Kv7.2/3 activation. Kv7.2/Kv7.3 activator-3 has anti-epileptic effects in epileptic seizure models. Kv7.2/Kv7.3 activator-3 reduces pain hypersensitivity in patients with diabetic neuropathy, promotes neuronal survival and regeneration after cervical neuropathy in rats, and accelerates the recovery of normal function of sensory and motor neurons[1][2][3][4].

Product Properties

• Molecular Weight: 436.40
• CAS Number: [1361107-81-4]
• Formula: C22H20F4N2O3
• Target: Potassium Channel,TSPO

Application Notes

• Application Notes: MCE Product type: Reference compound