AGPAT4-IN-1, CAS [[2411250-59-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: AGPAT4-IN-1, CAS [[2411250-59-2]] Preis auf Anfrage
• Artikelnummer: MCE-HY-175646
• Hersteller Artikelnummer: HY-175646
• Alternativnummer: MCE-HY-175646-25MG,MCE-HY-175646-5MG,MCE-HY-175646-10MG,MCE-HY-175646-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

AGPAT4-IN-1 (Compound CL26) is a covalent AGPAT4 inhibitor with an IC50 of 795 nM. AGPAT4-IN-1 covalently binds to AGPAT4 at Cys228 and significantly inhibits acyltransferase activity, LPA-to-PA conversion and downstream mTOR/S6K pathways. AGPAT4-IN-1 sensitizes hepatocellular carcinoma (HCC) tumors to Sorafenib (HY-10201) and significantly induces apoptosis with a synergistic response. AGPAT4-IN-1 has antitumor activity and reduces tumorigenicity and stemness in HCC xenograft mouse models[1].

Produkteigenschaften

• Molekulargewicht: 306.77
• CAS Nummer: [2411250-59-2]
• Formel: C14H11ClN2O2S
• Target-Kategorie: Acyltransferase,Apoptosis,mTOR,Ribosomal S6 Kinase (RSK)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound