RANKL-IN-1 is a selective and orally active Receptor Activator of Nuclear Factor-kappa B Ligand (RANKL) inhibitor with a KD value of 7.6 µM. RANKL-IN-1 exhibits inhibitory activity and selectivity against osteoclastogenesis with an IC50 value of 0.07 µM and SI of 82.57. RANKL-IN-1binds directly to RANKL and blocks the RANKL-induced activation of the NF-kappaB and MAPK pathways. RANKL-IN-1 can be used for the research of metabolic disease, such as osteoporosis[1].
Molekulargewicht:
621.90
Formel:
C40H55N5O
Target-Kategorie:
ERK,JNK,MMP,NF-kappaB,p38 MAPK,RANKL/RANK ,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
