RANKL-IN-1 is a selective and orally active Receptor Activator of Nuclear Factor-kappa B Ligand (RANKL) inhibitor with a KD value of 7.6 µM. RANKL-IN-1 exhibits inhibitory activity and selectivity against osteoclastogenesis with an IC50 value of 0.07 µM and SI of 82.57. RANKL-IN-1binds directly to RANKL and blocks the RANKL-induced activation of the NF-kappaB and MAPK pathways. RANKL-IN-1 can be used for the research of metabolic disease, such as osteoporosis[1].
Molecular Weight:
621.90
Formula:
C40H55N5O
Target:
ERK,JNK,MMP,NF-kappaB,p38 MAPK,RANKL/RANK ,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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