(7R)-Eras-4001, CAS [[3024878-21-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: (7R)-Eras-4001, CAS [[3024878-21-2]] Preis auf Anfrage
• Artikelnummer: MCE-HY-175870A
• Hersteller Artikelnummer: HY-175870A
• Alternativnummer: MCE-HY-175870A-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

(7R)-Eras-4001 is an orally active KRAS mutant inhibitor with remarkable selectivity for H-RAS and N-RAS. (7R)-Eras-4001 effectively suppresses cancer cell viability by blocking downstream signaling pathways mediated by RAF family proteins, inhibiting the formation of the KRASG12D-RAF1 RBD complex and the phosphorylation of ERK1/2. (7R)-Eras-4001 induces tumor growth inhibition and regression in a dose-dependent manner, and also reduces plasma ERK1/2 phosphorylation levels. (7R)-Eras-4001 exerts a synergistic effect with anti-PD-1 Cetuximab (HY-P9905). (7R)-Eras-4001 can be used in research on non-small cell lung cancer, pancreatic cancer, colorectal cancer, and ovarian cancer[1][2].

Produkteigenschaften

• Molekulargewicht: 743.19
• CAS Nummer: [3024878-21-2]
• Formel: C36H39ClF4N8O3
• Target-Kategorie: ERK,Ras

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound