(7R)-Eras-4001, CAS [[3024878-21-2]] Preis auf Anfrage

Product Overview

• Article Name: (7R)-Eras-4001, CAS [[3024878-21-2]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-175870A
• Supplier Catalog Number: HY-175870A
• Alternative Catalog Number: MCE-HY-175870A-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

(7R)-Eras-4001 is an orally active KRAS mutant inhibitor with remarkable selectivity for H-RAS and N-RAS. (7R)-Eras-4001 effectively suppresses cancer cell viability by blocking downstream signaling pathways mediated by RAF family proteins, inhibiting the formation of the KRASG12D-RAF1 RBD complex and the phosphorylation of ERK1/2. (7R)-Eras-4001 induces tumor growth inhibition and regression in a dose-dependent manner, and also reduces plasma ERK1/2 phosphorylation levels. (7R)-Eras-4001 exerts a synergistic effect with anti-PD-1 Cetuximab (HY-P9905). (7R)-Eras-4001 can be used in research on non-small cell lung cancer, pancreatic cancer, colorectal cancer, and ovarian cancer[1][2].

Product Properties

• Molecular Weight: 743.19
• CAS Number: [3024878-21-2]
• Formula: C36H39ClF4N8O3
• Target: ERK,Ras

Application Notes

• Application Notes: MCE Product type: Reference compound