KRAS-IN-43 (Compound 9) is a pan-KRAS inhibitor with IC50 values of 0.15 µM, 0.14 µM, and 0.47 µM against KRASG12V, KRASG12C and wild-type KRAS, respectively. KRAS-IN-43 disrupts the interaction between KRAS and cRAF, and inhibits ERK phosphorylation. KRAS-IN-43 is promising for research of KRAS mutation-related cancers (such as pancreatic cancer, colorectal cancer, and lung cancer)[1].
Molekulargewicht:
484.56
Formel:
C30H29FN2O3
Target-Kategorie:
ERK,Ras
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
