KRAS-IN-43 (Compound 9) is a pan-KRAS inhibitor with IC50 values of 0.15 µM, 0.14 µM, and 0.47 µM against KRASG12V, KRASG12C and wild-type KRAS, respectively. KRAS-IN-43 disrupts the interaction between KRAS and cRAF, and inhibits ERK phosphorylation. KRAS-IN-43 is promising for research of KRAS mutation-related cancers (such as pancreatic cancer, colorectal cancer, and lung cancer)[1].
Molecular Weight:
484.56
Formula:
C30H29FN2O3
Target:
ERK,Ras
Application Notes:
MCE Product type: Reference compound
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