ARN25657 is a dual-acting D3R/GSK-3beta modulator. ARN25657 has both partial D3R agonist activity (EC50 = 15.2 nM, Ki =1.5 nM) and potent GSK-3beta inhibitor activity (IC50 = 19.3 nM). ARN25657 exhibits excellent GSK-3beta selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-glycoprotein (P-gP)-mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders[1].
Molekulargewicht:
456.54
Formel:
C26H28N6O2
Target-Kategorie:
Dopamine Receptor,GSK-3,P-glycoprotein,PKA
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
