ARN25657 is a dual-acting D3R/GSK-3beta modulator. ARN25657 has both partial D3R agonist activity (EC50 = 15.2 nM, Ki =1.5 nM) and potent GSK-3beta inhibitor activity (IC50 = 19.3 nM). ARN25657 exhibits excellent GSK-3beta selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-glycoprotein (P-gP)-mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders[1].
Molecular Weight:
456.54
Formula:
C26H28N6O2
Target:
Dopamine Receptor,GSK-3,P-glycoprotein,PKA
Application Notes:
MCE Product type: Reference compound1
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