RGN6024 is a brain-penetrant, orally active and reversible small molecule tubulin destabilizer. RGN6024 inhibits microtubule polymerization both in biochemical and cellular assays, binds to the colchicine binding pocket of beta-tubulin (SPR: Kd = 6.7 µM, tryptophan assay: Kd = 7.4 µM), and triggers G2/M arrest in glioblastoma (GB) cells. RGN6024 retains activity in betaIII-tubulin overexpressing cells. RGN6024 inhibits tumor growth in a GB xenograft mouse model. RGN6024 can be used for the study of glioblastoma (GB)[1].
Molekulargewicht:
403.46
CAS Nummer:
[3055038-20-2]
Formel:
C18H21N5O4S
Target-Kategorie:
Microtubule/Tubulin
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
