RGN6024 is a brain-penetrant, orally active and reversible small molecule tubulin destabilizer. RGN6024 inhibits microtubule polymerization both in biochemical and cellular assays, binds to the colchicine binding pocket of beta-tubulin (SPR: Kd = 6.7 µM, tryptophan assay: Kd = 7.4 µM), and triggers G2/M arrest in glioblastoma (GB) cells. RGN6024 retains activity in betaIII-tubulin overexpressing cells. RGN6024 inhibits tumor growth in a GB xenograft mouse model. RGN6024 can be used for the study of glioblastoma (GB)[1].
Molecular Weight:
403.46
CAS Number:
[3055038-20-2]
Formula:
C18H21N5O4S
Target:
Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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