ACBI-4, CAS [[3097985-19-5]]

Produktübersicht

• Artikelname: ACBI-4, CAS [[3097985-19-5]]
• Artikelnummer: MCE-HY-176792
• Hersteller Artikelnummer: HY-176792
• Alternativnummer: MCE-HY-176792-5MG,MCE-HY-176792-10MG,MCE-HY-176792-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS(on)) PROTAC degrader. ACBI-4 potently degrades KRASG12R with Ka values of 141 nM. ACBI-4 forms a stable ternary complex with VHL, triggering ubiquitination and KRAS degradation via the ubiquitin-proteasome system. ACBI-4 induces antiproliferative effects in KRAS mutant-driven cancer cells. ACBI-4 can be used for the research of KRAS mutant-driven cancer[1].

Produkteigenschaften

• Molekulargewicht: 970.20
• Reinheit: 98.01
• CAS Nummer: [3097985-19-5]
• Formel: C50H63N15O4S
• Target-Kategorie: PROTACs,Ras

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound1