ACBI-4, CAS [[3097985-19-5]]

Product Overview

• Article Name: ACBI-4, CAS [[3097985-19-5]]
• Biozol Catalog Number: MCE-HY-176792
• Supplier Catalog Number: HY-176792
• Alternative Catalog Number: MCE-HY-176792-5MG,MCE-HY-176792-10MG,MCE-HY-176792-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS(on)) PROTAC degrader. ACBI-4 potently degrades KRASG12R with Ka values of 141 nM. ACBI-4 forms a stable ternary complex with VHL, triggering ubiquitination and KRAS degradation via the ubiquitin-proteasome system. ACBI-4 induces antiproliferative effects in KRAS mutant-driven cancer cells. ACBI-4 can be used for the research of KRAS mutant-driven cancer[1].

Product Properties

• Molecular Weight: 970.20
• Purity: 98.01
• CAS Number: [3097985-19-5]
• Formula: C50H63N15O4S
• Target: PROTACs,Ras

Application Notes

• Application Notes: MCE Product type: Reference compound1