SKLB-Y13 is a selective YTHDF1 inhibitor with an IC50 of 0.76 µM and a KD of 5.097 µM. SKLB-Y13 binds to the Tyr397 and Trp470 residues in the m6A-binding pocket of YTHDF1, disrupting the interaction between YTHDF1 and m6A-modified mRNA. SKLB-Y13 inhibits cancer cell proliferation and promotes apoptosis. SKLB-Y13 is applicable to breast cancer-related research[1].
Molekulargewicht:
514.43
Reinheit:
98.44
Formel:
C23H21Cl2N7OS
Target-Kategorie:
Apoptosis,Caspase,MMP,YTHDF
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
