SKLB-Y13 is a selective YTHDF1 inhibitor with an IC50 of 0.76 µM and a KD of 5.097 µM. SKLB-Y13 binds to the Tyr397 and Trp470 residues in the m6A-binding pocket of YTHDF1, disrupting the interaction between YTHDF1 and m6A-modified mRNA. SKLB-Y13 inhibits cancer cell proliferation and promotes apoptosis. SKLB-Y13 is applicable to breast cancer-related research[1].
Molecular Weight:
514.43
Purity:
98.44
Formula:
C23H21Cl2N7OS
Target:
Apoptosis,Caspase,MMP,YTHDF
Application Notes:
MCE Product type: Reference compound1
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