SKLB-Y13 is a selective YTHDF1 inhibitor with an IC50 of 0.76 ?µM. SKLB-Y13 binds to the m6A recognition pocket and disrupts m6A-dependent YTHDF1-PRPF6 mRNA interaction, impairing the translation of PRPF6 and inhibiting breast cancer proliferation while promoting apoptosis. SKLB-Y13 has antitumor activity, promising for cancers therapies targeting RNA epigenetic Readers[1].
Molecular Weight:
514.43
Purity:
95.62
Formula:
C23H21Cl2N7OS
Target:
Apoptosis,YTHDF
Application Notes:
MCE Product type: Reference compound
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