TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a KD of 3.962 µM. TMLB-C16 suppresses proliferation and migration, and induces cell cycle arrest and apoptosis in MHCC-97H (IC50 = 6.53 µM) and HCCLM3 cells (IC50 = 6.22 µM). TMLB-C16 inhibits tumor growth in both MHCC-97H and HCCLM3 xenograft tumor mouse models without causing obvious toxicity. TMLB-C16 can be used for hepatocellular carcinoma research[1].
Molekulargewicht:
453.88
CAS Nummer:
[2923531-50-2]
Formel:
C23H20ClN3O5
Target-Kategorie:
Apoptosis,Caspase,CDK,PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
