TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a KD of 3.962 µM. TMLB-C16 suppresses proliferation and migration, and induces cell cycle arrest and apoptosis in MHCC-97H (IC50 = 6.53 µM) and HCCLM3 cells (IC50 = 6.22 µM). TMLB-C16 inhibits tumor growth in both MHCC-97H and HCCLM3 xenograft tumor mouse models without causing obvious toxicity. TMLB-C16 can be used for hepatocellular carcinoma research[1].
Molecular Weight:
453.88
CAS Number:
[2923531-50-2]
Formula:
C23H20ClN3O5
Target:
Apoptosis,Caspase,CDK,PARP
Application Notes:
MCE Product type: Reference compound
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