STAT3-IN-52, CAS [[1556861-34-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: STAT3-IN-52, CAS [[1556861-34-7]] Preis auf Anfrage
• Artikelnummer: MCE-HY-177990
• Hersteller Artikelnummer: HY-177990
• Alternativnummer: MCE-HY-177990-5MG,MCE-HY-177990-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

STAT3-IN-52 (Compound 9) is a selective and orally active signal transducer and activator of transcription 3 (STAT3) inhibitor. STAT3-IN-52 binds to the pY705 site of STAT3 (Ki = 440 nM), blocking the phosphorylation and dimerization of STAT3. STAT3-IN-52 shows strong cytotoxicity against various cancer cells, such as breast cancer MDA-MB-231 (IC50 = 0.7 µM), medulloblastoma UW426, pancreatic cancer BKPC3 cells. STAT3-IN-52 can induce cell apoptosis, inhibit the STAT3 nuclear transport and DNA binding activity and downregulate the expression of the STAT3 target gene MMP9. STAT3-IN-52 can be used for research related to STAT3 abnormal activation in cancer[1].

Produkteigenschaften

• Molekulargewicht: 412.46
• CAS Nummer: [1556861-34-7]
• Formel: C20H20N4O4S
• Target-Kategorie: Apoptosis,MMP,STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound