STAT3-IN-52, CAS [[1556861-34-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-177990
Supplier Catalog Number:
HY-177990
Alternative Catalog Number:
MCE-HY-177990-5MG,MCE-HY-177990-10MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
STAT3-IN-52 (Compound 9) is a selective and orally active signal transducer and activator of transcription 3 (STAT3) inhibitor. STAT3-IN-52 binds to the pY705 site of STAT3 (Ki = 440 nM), blocking the phosphorylation and dimerization of STAT3. STAT3-IN-52 shows strong cytotoxicity against various cancer cells, such as breast cancer MDA-MB-231 (IC50 = 0.7 µM), medulloblastoma UW426, pancreatic cancer BKPC3 cells. STAT3-IN-52 can induce cell apoptosis, inhibit the STAT3 nuclear transport and DNA binding activity and downregulate the expression of the STAT3 target gene MMP9. STAT3-IN-52 can be used for research related to STAT3 abnormal activation in cancer[1].
Molecular Weight:
412.46
CAS Number:
[1556861-34-7]
Formula:
C20H20N4O4S
Target:
Apoptosis,MMP,STAT
Application Notes:
MCE Product type: Reference compound
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