PRMT5-IN-53, CAS [[3113303-04-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: PRMT5-IN-53, CAS [[3113303-04-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-178028
• Hersteller Artikelnummer: HY-178028
• Alternativnummer: MCE-HY-178028-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PRMT5-IN-53 is a gut-restricted and orally active PRMT5 inhibitor with pIC50s of 9.7 against hPRMT5 and mPRMT5. PRMT5-IN-53 binds to the PRMT5:MEP50 complex with a KD of 11.3 pM. PRMT5-IN-53 effectively inhibits PRMT5 locally in the intestines of mice, significantly reducing the number and area of polyps, while avoiding systemic hematological toxicity (such as anemia, neutropenia). PRMT5-IN-53 can be used for the study of colorectal cancer especially for familial adenomatous polyposis (FAP)[1].

Produkteigenschaften

• Molekulargewicht: 390.44
• CAS Nummer: [3113303-04-8]
• Formel: C21H22N6O2
• Target-Kategorie: Histone Methyltransferase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound