PRMT5-IN-53, CAS [[3113303-04-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-178028
Supplier Catalog Number:
HY-178028
Alternative Catalog Number:
MCE-HY-178028-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PRMT5-IN-53 is a gut-restricted and orally active PRMT5 inhibitor with pIC50s of 9.7 against hPRMT5 and mPRMT5. PRMT5-IN-53 binds to the PRMT5:MEP50 complex with a KD of 11.3 pM. PRMT5-IN-53 effectively inhibits PRMT5 locally in the intestines of mice, significantly reducing the number and area of polyps, while avoiding systemic hematological toxicity (such as anemia, neutropenia). PRMT5-IN-53 can be used for the study of colorectal cancer especially for familial adenomatous polyposis (FAP)[1].
Molecular Weight:
390.44
CAS Number:
[3113303-04-8]
Formula:
C21H22N6O2
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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