MRL-SYKi, CAS [[1312534-69-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: MRL-SYKi, CAS [[1312534-69-2]] Preis auf Anfrage
• Artikelnummer: MCE-HY-178129
• Hersteller Artikelnummer: HY-178129
• Alternativnummer: MCE-HY-178129-5MG,MCE-HY-178129-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

MRL-SYKi is a chemical probe with high selectivity and potent activity against spleen tyrosine kinase (SYK). MRL-SYKi potently binds to SYK gain-of-function (GoF) variants (SYK(S550Y), SYK(S550F), and SYK(P342T)) in intact live cells, with IC50 values of 2.1 nM, 14 nM, and 4.6 nM respectively in digitonin-permeabilized cell assays. MRL-SYKi effectively reduces catalytic activity (IC50 = 63 nM for SYK(S550F) and 95 nM for SYK(P342T) in PhosphoSens SOX peptide assays). MRL-SYKi can decrease the phosphorylation level of SYK(S550Y) at Y525/526 in SW480 cells. MRL-SYKi can be used for the study of inflammation[1].

Produkteigenschaften

• Molekulargewicht: 452.57
• Reinheit: 99.9
• CAS Nummer: [1312534-69-2]
• Formel: C24H28N4O3S
• Target-Kategorie: Syk

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound