E0199 is a novel potent dual-target KV7/NaV modulator that activates the KV7 channel (KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 µM), and KV7.5 (EC50 = 27.14 nM) channels) while simultaneously blocks the NaV1.7 (IC50 = 0.52 µM), NaV1.8 (IC50 = 0.24 µM), and NaV1.9 (IC50 = 0.16 µM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research[1].
Molekulargewicht:
535.63
Reinheit:
99.89
CAS Nummer:
[931928-13-1]
Formel:
C29H37N5O5
Target-Kategorie:
Potassium Channel,Sodium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
