E0199 is a novel potent dual-target KV7/NaV modulator that activates the KV7 channel (KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 µM), and KV7.5 (EC50 = 27.14 nM) channels) while simultaneously blocks the NaV1.7 (IC50 = 0.52 µM), NaV1.8 (IC50 = 0.24 µM), and NaV1.9 (IC50 = 0.16 µM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research[1].
Molecular Weight:
535.63
Purity:
99.89
CAS Number:
[931928-13-1]
Formula:
C29H37N5O5
Target:
Potassium Channel,Sodium Channel
Application Notes:
MCE Product type: Reference compound
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