GPX4-IN-19 is an effective GPX4 inhibitor (IC50 = 0.311 µM), covalently binds to the Sec 46 site of GPX4. GPX4-IN-19 shows strong anti-proliferative activity with high ferroptosis selectivity. GPX4-IN-19 causes intracellular Fe accumulation, leading to increased levels of lipid peroxides (LPOs) and reactive oxygen species (ROS), which induces ferroptosis and subsequently results in DNA damage. GPX4-IN-19 can be used for the study of Triple-Negative Breast Cancer (TNBC)[1].
Molekulargewicht:
395.81
Reinheit:
99.45
CAS Nummer:
[3102894-57-2]
Formel:
C19H19ClFNO5
Target-Kategorie:
DNA/RNA Synthesis,Ferroptosis,Glutathione Peroxidase,Lipoxygenase,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
