GPX4-IN-19 is an effective GPX4 inhibitor (IC50 = 0.311 µM), covalently binds to the Sec 46 site of GPX4. GPX4-IN-19 shows strong anti-proliferative activity with high ferroptosis selectivity. GPX4-IN-19 causes intracellular Fe accumulation, leading to increased levels of lipid peroxides (LPOs) and reactive oxygen species (ROS), which induces ferroptosis and subsequently results in DNA damage. GPX4-IN-19 can be used for the study of Triple-Negative Breast Cancer (TNBC)[1].
Molecular Weight:
395.81
Purity:
99.45
CAS Number:
[3102894-57-2]
Formula:
C19H19ClFNO5
Target:
DNA/RNA Synthesis,Ferroptosis,Glutathione Peroxidase,Lipoxygenase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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