BRAFV600E/ABL2-IN-1 is a BRAFV600E (IC50 = 0.088 µM)/ABL2 (IC50 = 0.3 µM) dual inhibitor. BRAFV600E/ABL2-IN-1 can diminish P-glycoprotein expression. BRAFV600E/ABL2-IN-1 effectively inhibits p-CrkL (Abl2 signaling) and p-ERK1/2 (BRAFV600E pathway) in A375-R melanoma cells. BRAFV600E/ABL2-IN-1 causes cell cycle arrest at the G1 phase, inhibiting progression to the S phase and subsequent phases and G2/M phase. BRAFV600E/ABL2-IN-1 significantly increases the percentage of late apoptotic cells. BRAFV600E/ABL2-IN-1 can be used for the study of melanoma[1].
Molekulargewicht:
559.86
Formel:
C24H20BrClN4O3S
Target-Kategorie:
Apoptosis,Bcr-Abl,PERK,P-glycoprotein,Raf
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
