BRAFV600E/ABL2-IN-1 is a BRAFV600E (IC50 = 0.088 µM)/ABL2 (IC50 = 0.3 µM) dual inhibitor. BRAFV600E/ABL2-IN-1 can diminish P-glycoprotein expression. BRAFV600E/ABL2-IN-1 effectively inhibits p-CrkL (Abl2 signaling) and p-ERK1/2 (BRAFV600E pathway) in A375-R melanoma cells. BRAFV600E/ABL2-IN-1 causes cell cycle arrest at the G1 phase, inhibiting progression to the S phase and subsequent phases and G2/M phase. BRAFV600E/ABL2-IN-1 significantly increases the percentage of late apoptotic cells. BRAFV600E/ABL2-IN-1 can be used for the study of melanoma[1].
Molecular Weight:
559.86
Formula:
C24H20BrClN4O3S
Target:
Apoptosis,Bcr-Abl,PERK,P-glycoprotein,Raf
Application Notes:
MCE Product type: Reference compound
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