WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC50 value of 1.33 µM. WCY-8-67 TFA induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways. WCY-8-67 TFA inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 TFA demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 TFA can be used for the study of acute myeloid leukemia[1].
Molekulargewicht:
905.66
Reinheit:
99.40
Formel:
C33H36F13N7O8
Target-Kategorie:
Akt,Apoptosis,Deubiquitinase,JAK,PI3K,STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
