WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC50 value of 1.33 µM. WCY-8-67 TFA induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways. WCY-8-67 TFA inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 TFA demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 TFA can be used for the study of acute myeloid leukemia[1].
Molecular Weight:
905.66
Purity:
99.40
Formula:
C33H36F13N7O8
Target:
Akt,Apoptosis,Deubiquitinase,JAK,PI3K,STAT
Application Notes:
MCE Product type: Reference compound
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