PTPN2/1-IN-4, CAS [[3093350-55-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: PTPN2/1-IN-4, CAS [[3093350-55-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-178716
• Hersteller Artikelnummer: HY-178716
• Alternativnummer: MCE-HY-178716-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNgamma-JAK-STAT signaling pathway and significantly augments CD8+ T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models[1].

Produkteigenschaften

• Molekulargewicht: 422.47
• CAS Nummer: [3093350-55-8]
• Formel: C19H23FN4O4S
• Target-Kategorie: IFNAR,JAK,Phosphatase,STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound