PTPN2/1-IN-4, CAS [[3093350-55-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-178716
Supplier Catalog Number:
HY-178716
Alternative Catalog Number:
MCE-HY-178716-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNgamma-JAK-STAT signaling pathway and significantly augments CD8+ T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models[1].
Molecular Weight:
422.47
CAS Number:
[3093350-55-8]
Formula:
C19H23FN4O4S
Target:
IFNAR,JAK,Phosphatase,STAT
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
