ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC50 of 7.0 nM for ROCK2 over ROCK1. ROCK2-IN-12 has potent antifibrotic effects via the TGF-beta/Smad and ROCK2/STAT3 signaling pathways. ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrotic progression in Bleomycin (HY-108345)-induced pulmonary fibrosis (PF) mouse models. ROCK2-IN-12 can be used for lung diseases like pulmonary fibrosis research[1].
Molekulargewicht:
455.45
Reinheit:
98.02
CAS Nummer:
[3086603-12-2]
Formel:
C23H18FN9O
Target-Kategorie:
ROCK,STAT,TGF-beta/Smad
Anwendungsbeschreibung:
MCE Product type: Reference compound
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