TGF-beta/Smad-IN-3, CAS [[3100351-69-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: TGF-beta/Smad-IN-3, CAS [[3100351-69-4]] Preis auf Anfrage
• Artikelnummer: MCE-HY-179042
• Hersteller Artikelnummer: HY-179042
• Alternativnummer: MCE-HY-179042-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

TGF-beta/Smad-IN-3 (Compound 4w) is an effective TGF-beta/Smad inhibitor. TGF-beta/Smad-IN-3 exerts anti-pulmonary fibrosis activity by simultaneously inhibiting the TGF-beta/Smad and MAPK signaling pathways. TGF-beta/Smad-IN-3 significantly inhibits collagen deposition induced by TGF-beta1, with its IC50 value being 3.21 µM. TGF-beta/Smad-IN-3 has an IC50 of 46.77 nM for the autocrine motility factor (ATX). TGF-beta/Smad-IN-3 significantly reduces the expression levels of alpha-SMA, COL1A1 and FN in TGF-beta1-induced CCC-HPF-1 cells, and effectively inhibited TGF-beta1-induced cell migration. TGF-beta/Smad-IN-3 can be used for the study of pulmonary fibrosis[1].

Produkteigenschaften

• Molekulargewicht: 697.85
• CAS Nummer: [3100351-69-4]
• Formel: C38H53F2N5O5
• Target-Kategorie: p38 MAPK,Phosphodiesterase (PDE),TGF-beta/Smad

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound