TGF-beta/Smad-IN-3, CAS [[3100351-69-4]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-179042
Supplier Catalog Number:
HY-179042
Alternative Catalog Number:
MCE-HY-179042-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
TGF-beta/Smad-IN-3 (Compound 4w) is an effective TGF-beta/Smad inhibitor. TGF-beta/Smad-IN-3 exerts anti-pulmonary fibrosis activity by simultaneously inhibiting the TGF-beta/Smad and MAPK signaling pathways. TGF-beta/Smad-IN-3 significantly inhibits collagen deposition induced by TGF-beta1, with its IC50 value being 3.21 µM. TGF-beta/Smad-IN-3 has an IC50 of 46.77 nM for the autocrine motility factor (ATX). TGF-beta/Smad-IN-3 significantly reduces the expression levels of alpha-SMA, COL1A1 and FN in TGF-beta1-induced CCC-HPF-1 cells, and effectively inhibited TGF-beta1-induced cell migration. TGF-beta/Smad-IN-3 can be used for the study of pulmonary fibrosis[1].
Molecular Weight:
697.85
CAS Number:
[3100351-69-4]
Formula:
C38H53F2N5O5
Target:
p38 MAPK,Phosphodiesterase (PDE),TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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