COX-2-IN-59 is a potent and selective COX-2 inhibitor with an IC50 of 0.052 µM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC50 = 11.16 µM). COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer[1].
Molekulargewicht:
405.42
Formel:
C18H19N3O6S
Target-Kategorie:
Apoptosis,Bcl-2 Family,Caspase,COX
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
