COX-2-IN-59 is a potent and selective COX-2 inhibitor with an IC50 of 0.052 µM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC50 = 11.16 µM). COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer[1].
Molecular Weight:
405.42
Formula:
C18H19N3O6S
Target:
Apoptosis,Bcl-2 Family,Caspase,COX
Application Notes:
MCE Product type: Reference compound
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