LXR agonist 4 is a selective LXR inverse agonist with IC50 values of 7.6 (LXRalpha) and 2.9 µM (LXRbeta), respectively. LXR agonist 4 exhibits selectivity over RORalpha and FXR. LXR agonist 4 robustly suppresses SREBP1c expression without altering ABCA1 or APOE. LXR agonist 4 displays antilipogenic properties and resolves fatty acid-induced steatosis. LXR agonist 4 can be used for the research of atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD)[1].
Molekulargewicht:
634.15
Formel:
C36H31ClF3NO2S
Target-Kategorie:
LXR
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
