LXR agonist 4 is a selective LXR inverse agonist with IC50 values of 7.6 (LXRalpha) and 2.9 µM (LXRbeta), respectively. LXR agonist 4 exhibits selectivity over RORalpha and FXR. LXR agonist 4 robustly suppresses SREBP1c expression without altering ABCA1 or APOE. LXR agonist 4 displays antilipogenic properties and resolves fatty acid-induced steatosis. LXR agonist 4 can be used for the research of atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD)[1].
Molecular Weight:
634.15
Formula:
C36H31ClF3NO2S
Target:
LXR
Application Notes:
MCE Product type: Reference compound1
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