DIM-3,5-Cl2, CAS [[2595179-74-9]]

Produktübersicht

• Artikelname: DIM-3,5-Cl2, CAS [[2595179-74-9]]
• Artikelnummer: MCE-HY-179528
• Hersteller Artikelnummer: HY-179528
• Alternativnummer: MCE-HY-179528-10MMX1ML, MCE-HY-179528-50MG, MCE-HY-179528-25MG, MCE-HY-179528-10MG, MCE-HY-179528-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with KD values of 7.7 µM and 12.0 µM for NR4A1 and NR4A2, respectively. DIM-3,5-Cl2 acts as an inverse agonist to downregulate pro-oncogenic and proendometriotic gene products, and as an agonist to enhance NR4A1/2/Sp1/Sp4-mediated CD71 transactivation. DIM-3,5-Cl2 induces ferroptosis via ROS formation, lipoperoxidation, MDA production, and reduced GPX4, SLC7A11 expression. DIM-3,5-Cl2 induces apoptosis via PARP and caspase-3 cleavage, reduced BCL-2 expression, and inhibits cancer cell viability. DIM-3,5-Cl2 can be used for the research of triple negative breast cancer, endometriosis, and colorectal cancer[1][2][3].

Produkteigenschaften

• Molekulargewicht: 391.29
• Reinheit: 99.18
• CAS Nummer: [2595179-74-9]
• Formel: C23H16Cl2N2
• Target-Kategorie: Apoptosis,Bcl-2 Family,Caspase,Ferroptosis,Glutathione Peroxidase,Nuclear Hormone Receptor 4A/NR4A,Reactive Oxygen Species (ROS),Transferrin Receptor

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound