DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with KD values of 7.7 µM and 12.0 µM for NR4A1 and NR4A2, respectively. DIM-3,5-Cl2 acts as an inverse agonist to downregulate pro-oncogenic and proendometriotic gene products, and as an agonist to enhance NR4A1/2/Sp1/Sp4-mediated CD71 transactivation. DIM-3,5-Cl2 induces ferroptosis via ROS formation, lipoperoxidation, MDA production, and reduced GPX4, SLC7A11 expression. DIM-3,5-Cl2 induces apoptosis via PARP and caspase-3 cleavage, reduced BCL-2 expression, and inhibits cancer cell viability. DIM-3,5-Cl2 can be used for the research of triple negative breast cancer, endometriosis, and colorectal cancer[1][2][3].
Molecular Weight:
391.29
Purity:
99.18
CAS Number:
[2595179-74-9]
Formula:
C23H16Cl2N2
Target:
Apoptosis,Bcl-2 Family,Caspase,Ferroptosis,Glutathione Peroxidase,Nuclear Hormone Receptor 4A/NR4A,Reactive Oxygen Species (ROS),Transferrin Receptor
Application Notes:
MCE Product type: Reference compound
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