ZG-2686 is a potent and selective HIF-2alpha agonist with an EC50 of 0.25 µM. ZG-2686 exhibits selectivity over PHD2. ZG-2686 binds to a specific internal cavity of HIF-2alpha, forming hydrogen bonds via structural water molecules, which stabilizes the HIF-2alpha/beta heterodimer and enhances transcriptional activity. ZG-2686 synergizes with Vadadustat (HY-101277) to upregulate HIF-2alpha-dependent EPO gene expression both in vitro and in vivo. ZG-2686 can be used for the research of renal anemia[1].
Molekulargewicht:
317.14
CAS Nummer:
[1795110-22-3]
Formel:
C13H9BrN4O
Target-Kategorie:
HIF/HIF Prolyl-Hydroxylase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
