ZG-2686 is a potent and selective HIF-2alpha agonist with an EC50 of 0.25 µM. ZG-2686 exhibits selectivity over PHD2. ZG-2686 binds to a specific internal cavity of HIF-2alpha, forming hydrogen bonds via structural water molecules, which stabilizes the HIF-2alpha/beta heterodimer and enhances transcriptional activity. ZG-2686 synergizes with Vadadustat (HY-101277) to upregulate HIF-2alpha-dependent EPO gene expression both in vitro and in vivo. ZG-2686 can be used for the research of renal anemia[1].
Molecular Weight:
317.14
CAS Number:
[1795110-22-3]
Formula:
C13H9BrN4O
Target:
HIF/HIF Prolyl-Hydroxylase
Application Notes:
MCE Product type: Reference compound
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