CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimers disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function[1].
Molekulargewicht:
273.28
Reinheit:
99.81
CAS Nummer:
[923714-61-8]
Formel:
C15H15NO4
Target-Kategorie:
Cholecystokinin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
