CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway (EC50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimers disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function[1].
Molecular Weight:
273.28
Purity:
99.81
CAS Number:
[923714-61-8]
Formula:
C15H15NO4
Target:
Cholecystokinin Receptor
Application Notes:
MCE Product type: Reference compound
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