Grp94-IN-3 (Compound 47) is a selective ATP competitive inhibitor of Grp94, with a Kd value of 76 nM. Grp94-IN-3 has a much lower affinity for Hsp90alpha, with a Kd value of 9.17 µM. Grp94-IN-3 induces the degradation of integrin alpha2 (Integrin alpha2) in MDA-MB-231 cells and reduces the intracellular accumulation of mutant cardiac proteins in human trabecular meshwork cells. Grp94-IN-3 can be used for the study of metastatic cancer and open-angle glaucoma[1].
Molekulargewicht:
429.90
Formel:
C22H24ClN3O4
Target-Kategorie:
HSP,Integrin
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
