Grp94-IN-3 (Compound 47) is a selective ATP competitive inhibitor of Grp94, with a Kd value of 76 nM. Grp94-IN-3 has a much lower affinity for Hsp90alpha, with a Kd value of 9.17 µM. Grp94-IN-3 induces the degradation of integrin alpha2 (Integrin alpha2) in MDA-MB-231 cells and reduces the intracellular accumulation of mutant cardiac proteins in human trabecular meshwork cells. Grp94-IN-3 can be used for the study of metastatic cancer and open-angle glaucoma[1].
Molecular Weight:
429.90
Formula:
C22H24ClN3O4
Target:
HSP,Integrin
Application Notes:
MCE Product type: Reference compound
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