P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 µM in HT-29 cells. P2L-003 blocks PAR2-mediated Ca2+ mobilization without affecting PAR1, PAR4, or ATP-mediated signaling and dose-dependently suppresses the downstream MAPK signaling cascades, including ERK1/2 and p38 phosphorylation. P2L-003 can be used for colon cancer research[1].
Molekulargewicht:
472.99
CAS Nummer:
[1359416-20-8]
Formel:
C23H25ClN4O3S
Target-Kategorie:
p38 MAPK,Protease Activated Receptor (PAR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
