P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 µM in HT-29 cells. P2L-003 blocks PAR2-mediated Ca2+ mobilization without affecting PAR1, PAR4, or ATP-mediated signaling and dose-dependently suppresses the downstream MAPK signaling cascades, including ERK1/2 and p38 phosphorylation. P2L-003 can be used for colon cancer research[1].
Molecular Weight:
472.99
CAS Number:
[1359416-20-8]
Formula:
C23H25ClN4O3S
Target:
p38 MAPK,Protease Activated Receptor (PAR)
Application Notes:
MCE Product type: Reference compound
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